Oncoproteins destroy vital tumor-suppressorTwo previously unconnected cancer-promoting proteins team up to ambush a critical tumor suppressor by evicting it from the cell's nucleus and then marking it for death by a protein-shredding mechanism, a team led by researchers at The University of Texas M. D. Anderson Cancer Center reports in the Feb. 10 issue of Nature Cell Biology.
The paper is the first to illuminate a mechanism of attack on FOXO3a, a member of the forkhead family of........Go to the Cancer-blog (Added on 2/14/2008 10:17:57 PM)
Lnk between cancer, Down syndromeTheres new hope for breast cancer research, and its coming from a very unlikely place. Scientists at the Texas A&M University College of Veterinary Medicine & Biomedical Sciences recently published articles in the journals Molecular and Cellular Biology and Carcinogenesis indicating that a protein long suspected to play a role in Down Syndrome may also contribute to treating this devastating disease.
It has long been known that Down Syndrome........Go to the Cancer-blog (Added on 2/4/2008 9:24:45 PM)
Folic acid lowers blood arsenic levelsA new study conducted in Bangladesh finds that folic acid supplements can dramatically lower blood arsenic levels in individuals chronically exposed to arsenic-contaminated drinking water. Arsenic is a toxic element that is naturally present in some soils and water. Arsenic-contaminated drinking water is currently a significant public health problem in at least 70 countries, including several developing countries and also parts of the United........Go to the Health-blog (Added on 10/10/2007 5:21:14 PM)
Nonsmall cell lung cancer: chemotherapy before surgeryCombining pre-operative chemotherapy and surgery increases the average chance of survival at five years by approximately 6% compared with surgery alone.
This conclusion was drawn by a team of Cochrane Researchers from the MRC Clinical Trials Unit in London after they identified 12 eligible randomised controlled trials. Data from seven of these trials were available from trial reports and were combined in a meta-analysis. The seven trials........Go to the Cancer-blog (Added on 7/19/2007 10:04:18 PM)
"Tarts" cancer jab will "ruin lives"
"Gardasil is almost 100% effective against Human Papilloma Virus, the main cause of cervical cancer, which can be fatal, and genital warts. It is now being prescribed in Britain , with calls for the 'wonder drug' to be administered wholesale to school-girls. Cervical cancer charity Jo's Trust has called for a nation-wide........Go to the Cancer-blog (Added on 6/21/2007 9:04:25 PM)
(Added on 7/19/2007 10:04:18 PM)
Target tumor microenvironment to stop cancer growthCold Spring Harbor Laboratory (CSHL) researchers led by Daniel Nolan and Assistant Professor Vivek Mittal have found that bone marrow (BM) derived endothelial progenitor cells (EPCs) play a critical role in the early stages of tumor progression and that eliminating EPCs stops cancer growth. Using sophisticated high-resolution microscopy and flow cytometry, they zeroed in on the earliest stages of cancer progression and identified the role of........Go to the Cancer-blog (Added on 6/15/2007 12:24:56 PM)
Sleep problems may affect a person's dietSleep problems can influence a persons diet. Those who dont get enough sleep are less likely to cook their own meals and, instead, opt to eat fast food. It is the lack of nutritional value of this restaurant-prepared food that may cause health problems for these people in the long-run, as per a research abstract that will be presented Monday at SLEEP 2007, the 21st Annual Meeting of the Associated Professional Sleep Societies (APSS).
Mindy........Go to the Health-blog (Added on 6/12/2007 5:10:38 AM)
Stem cells provide clues to cancer spreadScientists have made a breakthrough in understanding how cancers spread in what could lead to new ways of beating the disease.
The University of Manchester study used embryonic stem (ES) cells to investigate how some tumours are able to migrate to other parts of the body, which makes the treatment of cancer much more difficult.
Dr Chris Ward, in the Universitys Faculty of Medical and Human Sciences, studied a crucial change that makes........Go to the Cancer-blog (Added on 5/22/2007 9:51:16 PM)
The Tungsten Nevada Leukemia LinkTungsten began increasing in trees in Fallon, Nev. several years before the town's rise in childhood leukemia cases, according to a new research report.
The amount of tungsten in tree rings from Fallon quadrupled between 1990 and 2002, whereas the amount in tree rings from nearby towns remained the same, according to a research team led by Paul R. Sheppard of The University of Arizona's Laboratory of Tree-Ring Research.
This is the first........Go to the Cancer-blog (Added on 4/30/2007 6:54:26 PM)
High insulin levels impair intestinal metabolic functionNutritional scientists at the University of Alberta are the first to establish a connection between high insulin levels and dysfunction of intestinal lipid metabolism in an animal model. They believe this finding supports their contention that impaired intestinal metabolic function plays a critical role in the development of cardiovascular disease.
The research was published recently in the journal Atherosclerosis.
The researchers have........Go to the Health-blog (Added on 4/24/2007 10:27:06 PM)
MicroRNAs as tumor suppressorsIn the May 1st issue of G&D, Drs. Yong Sun Lee and Anindya Dutta (UVA) reveal that microRNAs can function as tumor suppressors in vitro.
"Overexpression of HMGA2 is an important feature of a number of medically important tumors like uterine fibroids, explains Dr. Dutta. It is very exciting to realize that microRNAs have an important role in suppressing the overexpression of HMGA2, and so may have a role in the causation and perhaps the cure........Go to the Cancer-blog (Added on 4/15/2007 8:53:10 PM)
Deadly Secrets Of Ovarian CancerA new University of Michigan Medical School study sheds light on cell defects that lead to one common type of ovary cancer and puts forth a promising new mouse model that already is being used for preclinical drug testing.
The study, reported in the recent issue of Cancer Cell, focuses on ovarian endometrioid adenocarcinoma, the second most common form of a baffling, deadly disease for which early detection methods and effective therapys........Go to the Cancer-blog (Added on 4/11/2007 11:02:56 PM)
The formation of social memoriesIs there a specific memory for events involving people? Researchers in the Vulnerability, Adaptation and Psychopathology Laboratory (CNRS/University Paris VI France ) and a Canadian team at Douglas Hospital, McGill University (Montreal), have identified the internal part of the prefrontal cortex as being the key structure for memorising social information. Published in Journal of Cognitive Neuroscience, February 2007.
Social events such as........Go to the Health-blog (Added on 4/1/2007 9:33:52 PM)
Genetic Risk Factors For Prostate CancerA study led by researchers at the Keck School of Medicine of the University of Southern California (USC) and Harvard Medical School has identified seven genetic risk factorsDNA sequences carried by some people but not othersthat predict risk for prostate cancer. According to the study's findings, these risk factors are clustered in a single region of the human genome on chromosome 8 and powerfully predict a man's probability of developing........Go to the Cancer-blog (Added on 4/1/2007 9:19:36 PM)
The House of the DeadIf you get caught with your hands in the till, it is best to own up. If you are a politician, it is best to own up quietly. People might not notice. And there is no better place in which to own up than the House of the DeadThe Ferret Fancier (why does he call himself that?) has been delving around in the annals of the House of the Dead, and has caught Lord Hunt "in flagrante".Delicious.Patsy has been pretending that the selection of junior........Go to the News-blog (Added on 3/28/2007 9:40:47 PM)
Cancer Gene Work By Destroying MessengerA new study suggests how a notorious cancer gene may contribute to tumor growth.
The insight emerged from a long-running study of a protein called PMR1, the key player in an unusual mechanism that cells use to quickly stop production of certain important proteins.
Researchers discovered that PMR1 is activated - or "turned on - by another molecule, an energy-packing protein called Src (pronounced "sark").
Discovered in 1977, Src became........Go to the Cancer-blog (Added on 3/19/2007 10:04:08 PM)
Surveillance In Colorectal Cancer Patients Improves SurvivalColorectal cancer patients who undergo colonoscopic surveillance during follow-up after surgery experience improved survival, according to a study would be published in the recent issue of Clinical Gastroenterology and Hepatology but currently available on-line. Results of the study suggest that colorectal cancer patients should undergo routine colonoscopic surveillance at one year after their surgery and that more intensive surveillance may be........Go to the Cancer-blog (Added on 3/15/2007 9:27:15 PM)
Receptor For Alcohol Pleasure And ProblemsA genetic variant of a receptor in the brains reward circuitry heightens the stimulating effects of early exposures to alcohol and increases alcohol consumption, according to a new study by researchers at the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health (NIH). Conducted in rhesus monkeys, the study extends previous research that suggests an important role for a similar brain receptor........Go to the Health-blog (Added on 3/6/2007 3:32:39 PM)
Pink Motivation For Cool Girls
I'm a huge fan of kits. The cutest, the better.
This one is for the girl who loves cute, pink, useful kits: Pink Gym Kit
In my opinion, the Pink Gym Kit is an extra help to keep you from missing your exercise appointments.
You'll feel like going to the gym, just to use these pretty, cool things!
Pink Gym Kit includes:
- Pedometer........Go to the Cancer-blog (Added on 3/2/2007 7:56:45 PM)
Few Primary Care Practitioners Offer HIV Tests Even as the AIDS epidemic in Los Angeles County has shifted largely to Hispanics, primary care practitioners serving this segment of the population often fail to offer either HIV testing or safer sex advice to their patients, according to a new UCLA AIDS Institute study.
The study, published in the recent issue of the Journal of the National Medical Association, found that only 41 percent of these primary care providers including doctors,........Go to the News-blog (Added on 3/1/2007 5:04:27 AM)
Cancer risk higher for women in discontinued hormone treatment trialA follow up study of participants in the Womens Health Initiative (WHI) clinical trial led by a University of North Carolina at Chapel Hill researcher has observed that women who were taking the combined hormone treatment of estrogen plus progestin may have an increased risk of cancer since the intervention was stopped, in comparison to participants in the trials placebo group.
However, the increased risks of heart disease, stroke and blood........Go to the Cancer-blog (Added on 3/4/2008 6:03:05 PM)
How to switch off cancer cell genesA new study led by scientists at the University of Southern California (USC) identifies how genes are silenced in cancer cells through distinct changes in the density of nucleosomes within the cells.
The findings, reported in the Nov. 13 issue of the journal Cancer Cell, will enable scientists to explore new therapies to switch the genes back on and may lead to novel therapys for human cancers, says study lead author Peter A. Jones, Ph.D.,........Go to the Cancer-blog (Added on 11/12/2007 10:08:17 PM)
New strategies with greater antitumorous efficacyOne of the biggest problems in the current therapy of cancer is that the agents that are efficacious in the destruction of tumorous cells are, at the same time, extremely toxic for the rest of the healthy cells and tissues of the patient. To address the problem the University of the Basque Country (UPV/EHU) is seeking more specific therapys and studying the differences between tumorous cells and healthy ones.
A research team from the Faculty........Go to the Cancer-blog (Added on 10/2/2007 10:28:05 PM)
Light-activated Molecules To Kill Cancer CellsA key challenge facing doctors as they treat patients suffering from cancer or other diseases resulting from genetic mutations is that the drugs at their disposal often dont discriminate between healthy cells and dangerous ones -- think of the brute-force approach of chemotherapy, for instance. To address this challenge, Florida State University scientists are investigating techniques for using certain molecules that, when exposed to light,........Go to the Cancer-blog (Added on 8/8/2007 8:44:21 PM)
Impact of False-positive Cancer TestsAccording to a new study in Value in Health, women coping with the strain of being mistakenly diagnosed with breast cancer have not been adequately studied in the past. The focus of the study is a new survey that accurately assesses the negative effects of false diagnosis and provides useful information to health care practitioners and researchers.
"We know that having a false alarm at a breast cancer screening causes significant negative........Go to the Cancer-blog (Added on 7/19/2007 10:01:30 PM)
Prostate cancer risk in BRCA2 carriersCarriers of a BRCA2 variation specific to Iceland are more likely to develop aggressive and lethal prostate cancer than noncarriers, as per a research studypublished online June 12 in the Journal of the National Cancer Institute
Mutations in the BRCA2 gene are linked to increased prostate cancer risk, but it has been unclear whether they are correlation to progression of the disease.
Laufey Tryggvadttir of the Icelandic Cancer Registry........Go to the Cancer-blog (Added on 6/13/2007 1:24:33 PM)
"Nurse Cells" Make Life and Death Decisions"Nurse cells" play an important role in deciding which developing infection-fighting cells, called T cells, live and which die, according to research funded by the National Science Foundation (NSF) and reported in the recent issue of the journal Experimental Biology and Medicine.
The infection-fighting cells, known as thymocytes or T cells, live in the thymus, an organ in the upper portion of the chest. Loss of the thymus results in severe........Go to the Health-blog (Added on 6/10/2007 9:27:06 PM)
Role of age, gender, race and weight on cancer riskWhile cancer has been studied extensively to determine the major contributing factors for risk and ultimate outcome, a number of variables still remain and doctors are puzzled by new cases that do not fit "old" protocol. Research presented today at Digestive Disease Week 2007 (DDW) demonstrates improved results in determining these risks, including the relative "weight" of being heavy on risk for colon cancer; possible risk of cancer surgery........Go to the Cancer-blog (Added on 5/21/2007 12:30:53 PM)
MR imaging helps predict recurrenceMR images taken of patients with prostate cancer previous to therapy that show that the cancer has spread outside the prostate gland capsule help predict whether the cancer will return, as per a recent study conducted by radiologists at the University of California-San Francisco.
The study consisted of 74 men with biopsy-proven prostate cancer who underwent endorectal MR imaging of the prostate, said Antonio Westphalen, MD, lead author of........Go to the Cancer-blog (Added on 5/6/2007 5:50:23 PM)
Short chromosomes put cancer cells in forced restA Johns Hopkins team has stopped in its tracks a form of blood cancer in mice by engineering and inactivating an enzyme, telomerase, thereby shortening the ends of chromosomes, called telomeres.
"Normally, when telomeres get critically short, the cell commits suicide as a means of protecting the body," says Carol Greider, Ph.D., the Daniel Nathans chair of molecular biology and genetics at Johns Hopkins. Her study, appearing online this........Go to the Cancer-blog (Added on 4/25/2007 9:35:26 PM)
Antioxidant is selective killer of leukemia cellsA naturally occurring compound found in many fruits and vegetables as well as red wine, selectively kills leukemia cells in culture while showing no discernible toxicity against healthy cells, according to a study by researchers at the University of Pittsburgh School of Medicine. These findings, which were published online March 20 in the Journal of Biological Chemistry and will be in press on May 4, offer hope for a more selective, less toxic........Go to the Cancer-blog (Added on 4/23/2007 10:06:09 PM)
Misusing vitamin to foil drug testTaking excessive doses of a common vitamin in an attempt to defeat drug screening tests may send the user to the hospitalor worse.
Researchers from The Children's Hospital of Philadelphia and The University of Pennsylvania reported on two adults and two adolescents who suffered toxic side effects from taking large amounts of niacin, also known as vitamin B3, in mistaken attempts to foil urine drug tests.
Both adult patients suffered skin........Go to the Health-blog (Added on 4/10/2007 6:35:15 PM)
Flexible Electronics As SensorsFlexible electronic structures with the potential to bend, expand and manipulate electronic devices are being developed by researchers at the U.S. Department of Energy's Argonne National Laboratory and the University of Illinois at Urbana-Champaign. These flexible structures could find useful applications as sensors and as electronic devices that can be integrated into artificial muscles or biological tissues.
In addition to a biomedical........Go to the Health-blog (Added on 4/2/2007 10:18:16 PM)
Protein Averts Cell SuicideScientists have discovered how an unusual protein helps a cell bypass damage when making new DNA, thereby averting the cell's self-destruction.
But they also discovered that this protein, an enzyme called Dpo4, often makes errors when copying the genomic DNA sequence that later might cause the cell to become cancerous.
The findings by researchers with Ohio State University 's Comprehensive Cancer Center are described in two back-to-back........Go to the Cancer-blog (Added on 3/29/2007 10:40:07 PM)
Lack Of A Protein In Lung TumorsA study of human lung tumors indicates that lung cancer patients who lack a particular protein may do more poorly than those with normal levels of that same protein.
If the findings are verified in a clinical trial, the absence of the protein might be used to identify lung cancer patients who need more aggressive therapy after surgery.
The protein is the product of a gene called Olig1, which previously has not been linked with lung........Go to the Cancer-blog (Added on 3/29/2007 4:56:30 AM)
Low-dose aspirin Vs high-dose aspirinThe use of medicines to fight cardiovascular disease has been a primary focus of research in this area for the past several decades, as combinations of interventions and medicinal treatment have gradually begun to increase long-term survival rates. Two studies presented today at the American College of Cardiology's 56th Annual Scientific Session look at the measurable impact of the use of aspirin and other maintenance therapies, and one........Go to the Health-blog (Added on 3/25/2007 9:06:58 PM)
Chemical cues for embryonic stem cellsIn order to differentiate and specialize, stem cells require very specific environmental cues in a very specific order, and scientists have so far been unable to prod them to go through each of the necessary steps. But now, for the first time, a study in mice by Rockefeller University scientists shows that embryonic stem cells implanted in the brain appear to develop into fully differentiated granule neurons, the most plentiful neuron in the........Go to the News-blog (Added on 3/14/2007 10:27:17 PM)
Target For Treatment For LeukemiaAli Shilatifard, Ph.D., Investigator, has identified a cellular factor that can reverse histone trimethylation caused by the trithorax gene, the Drosophila homologue of the human mixed lineage leukemia gene, MLL. MLL, which is found in translocations in a variety of hematological malignancies, is a histone H3K4 methyltransferase.
The paper, "The trithorax-group gene little imaginal discs in Drosophila encodes a histone H3 trimethyl-Lys4........Go to the Cancer-blog (Added on 3/11/2007 8:32:56 PM)
Protein That Appears To Regulate Bone Mass LossTypically typically an estimated ten million americans suffer from osteoporosis, and another 34 million americans are at risk of developing the disease, which is characterized by a severe loss of bone mineral density, fragile bones and an increased risk of hip, spine and wrist fractures. The basic mechanism behind osteoporosis involves an imbalance between bone mineral formation and loss, but the detailed biological processes that lead to this........Go to the Health-blog (Added on 3/5/2007 9:58:17 PM)
Researchers Wake Up Viruses Inside TumorsResearchers have found a way to activate Epstein-Barr viruses inside tumors as a way to identify patients whose infection can then be manipulated to destroy their tumors. They say this strategy could offer a novel way of treating many cancers associated with Epstein-Barr, including at least four different types of lymphoma and nasopharyngeal and gastric cancers.
In the March 1 issue of Clinical Cancer Research, a team of radiologists and........Go to the Cancer-blog (Added on 3/1/2007 4:33:05 AM)