http://www.cancer-blog.org/ New Article Alert From From Cancer blog Fri, 19 Feb 2010 03:50:54 GMT en-us http://www.cancer-blog.org/images/blogs/new-article-alert-61900.jpg http://www.cancer-blog.org/ 135 90 http://www.cancer-blog.org/blogs/permalinks/2-2010/cancer-cell-migration.html http://www.cancer-blog.org/blogs/permalinks/2-2010/cancer-cell-migration.html Fri, 19 Feb 2010 03:50:54 GMT Investigators at Sanford-Burnham Medical Research Institute (Sanford-Burnham, formerly Burnham Institute for Medical Research) led by Kristiina Vuori, M.D., Ph.D., have discovered that the natural compound sceptrin, which is found in marine sponges, reduces cancer cell motility (movement) and has very low toxicity. Metastasis is one of the deadliest aspects of cancer, so restricting aberrant cell movement is an important step towards advancing therapys. The research was published online in ACS Chemical Biology, in collaboration with Phil S. Baran, Ph.D., of The Scripps Research Institute........ ]]> http://www.cancer-blog.org/blogs/permalinks/2-2010/how-to-kill-pediatric-brain-tumors.html http://www.cancer-blog.org/blogs/permalinks/2-2010/how-to-kill-pediatric-brain-tumors.html Fri, 19 Feb 2010 03:50:54 GMT Scientists at Washington University School of Medicine in St. Louis have shown once again that "ready, fire, aim," nonsensical though it may sound, can be an essential approach to research. The researchers robotically "fired" 2,000 compounds into culture plates containing tumor cells to see if the compounds had any effect. When the robotic screener found one substance had scored a hit by inhibiting growth of the tumor cells in its plate, scientists analyzed what that compound acted against. Follow-up studies showed that the drug slowed tumor growth in mice by inhibiting the function of a protein called STAT3........ ]]> http://www.cancer-blog.org/blogs/permalinks/2-2010/community-hospitals-as-safe-surgical-option.html http://www.cancer-blog.org/blogs/permalinks/2-2010/community-hospitals-as-safe-surgical-option.html Fri, 19 Feb 2010 03:50:54 GMT Low-risk patients who require certain cancer surgeries can have the procedures performed with low operative mortality rates at community hospitals, as per a newly released study. The research showed that for 13 different kinds of cancer surgeries such as gastric and colon, younger patients with few pre-existing illnesses survived operations at community hospitals at a similar rate as at cancer centers........ ]]> http://www.cancer-blog.org/blogs/permalinks/2-2010/quality-radiation-therapy.html http://www.cancer-blog.org/blogs/permalinks/2-2010/quality-radiation-therapy.html Fri, 19 Feb 2010 03:50:54 GMT The American Association of Physicists in Medicine (AAPM) has issued a statement today in the wake of several recent articles in the New York Times yesterday and earlier in the week that discuss many rare but tragic events in the last decade involving people undergoing radiation treatment. While it does not specifically comment on the details of these events, the statement acknowledges their gravity. It reads in part: "The AAPM and its members deeply regret that these events have occurred, and we continue to work hard to reduce the likelihood of similar events in the future." The full statement appears at: http://www.aapm.org/publicgeneral/QualityRadiationTherapy.asp........ ]]> http://www.cancer-blog.org/blogs/permalinks/2-2010/assessing-risks-of-radiation.html http://www.cancer-blog.org/blogs/permalinks/2-2010/assessing-risks-of-radiation.html Fri, 19 Feb 2010 03:50:54 GMT There remains a lack of consensus amongst the medical and scientific communities about any cancer risk from low level radiation, especially low-dose radiation delivered from computed tomography (CT) scans. However, the study of epigenetics may play a role in determining whether or not future trends of diseases can in fact be associated with utilization of CT, as per an article in the recent issue of the Journal of the American College of Radiology (JACR)........ ]]> http://www.cancer-blog.org/blogs/permalinks/1-2010/targeting-stem-cells-to-fight-ovarian-cancer.html http://www.cancer-blog.org/blogs/permalinks/1-2010/targeting-stem-cells-to-fight-ovarian-cancer.html Fri, 19 Feb 2010 03:50:54 GMT Eliminating cancer stem cells (CSCs) within a tumor could hold the key to successful therapys for ovary cancer, which has been notoriously difficult to detect and treat, as per new findings published this week in the journal Oncogene by Yale School of Medicine researchers. "We observed that stopping the expression of two genesLin28 and Oct4reduces ovary cancer cell growth and survival," said Yingqun Huang, M.D., assistant professor in the Department of Obstetrics, Gynecology and Reproductive Sciences at Yale School of Medicine........ ]]> http://www.cancer-blog.org/blogs/permalinks/1-2010/reversing-cancer-cell-metabolism-and-tumor-growth.html http://www.cancer-blog.org/blogs/permalinks/1-2010/reversing-cancer-cell-metabolism-and-tumor-growth.html Fri, 19 Feb 2010 03:50:54 GMT A team of researchers led by Professor Adrian Krainer, Ph.D., of Cold Spring Harbor Laboratory has discovered molecular factors in cancer cells that boost the production of an enzyme that helps alter the cells' glucose metabolism. The altered metabolic state, called the Warburg effect, promotes extremely rapid cell proliferation and tumor growth........ ]]> http://www.cancer-blog.org/blogs/permalinks/4-2009/improved-detection-of-bladder-tumors.html http://www.cancer-blog.org/blogs/permalinks/4-2009/improved-detection-of-bladder-tumors.html Fri, 19 Feb 2010 03:50:54 GMT Making tumors inside the bladder fluoresce red under blue light allows physicians to more easily find and remove them, substantially reducing the rate at which these cancers come back, says a Mayo Clinic doctor who is presenting results of a large, multicenter international clinical trial. VIDEO ALERT: Additional audio and video resources, including excerpts from an interview with Dr. Lance Mynderse describing the research, are available on the Mayo Clinic News Blog (http://newsblog.mayoclinic.org/)Mayo Clinic News Blog. These materials are also subject to embargo, but appears to be accessed in advance by journalists for incorporation into stories. The password for the post is hvxaua1........ ]]> http://www.cancer-blog.org/blogs/permalinks/4-2009/robotic-surgery-for-kidney-cancer.html http://www.cancer-blog.org/blogs/permalinks/4-2009/robotic-surgery-for-kidney-cancer.html Fri, 19 Feb 2010 03:50:54 GMT Fox Chase Cancer Center scientists find that outcomes of robotic assisted kidney cancer surgery, when performed by experienced surgeons at high volume centers, prove more beneficial to patients when in comparison to open surgery. The study, authored by Fox Chase robotic surgeon Rosalia Viterbo, MD, was presented today at the American Urological Association's Annual Meeting, ........ ]]> http://www.cancer-blog.org/blogs/permalinks/4-2009/sirt1-takes-down-tumors.html http://www.cancer-blog.org/blogs/permalinks/4-2009/sirt1-takes-down-tumors.html Fri, 19 Feb 2010 03:50:54 GMT Yuan et al. have identified another anti-cancer effect of the "longevity" protein SIRT1. By speeding the destruction of the tumor promoter c-Myc, SIRT1 curbs cell division. The study will be published online April 13 (www.jcb.org) and will appear in the April 20 print issue of the Journal of Cell Biology....... ]]> http://www.cancer-blog.org/blogs/permalinks/12-2008/how-radiation-causes-chronic-inflammation.html http://www.cancer-blog.org/blogs/permalinks/12-2008/how-radiation-causes-chronic-inflammation.html Fri, 19 Feb 2010 03:50:54 GMT The use of radiation treatment to treat cancer inevitably involves exposure of normal tissues. Eventhough the benefits of this therapy have been well established, many patients experience distressing complications as a result injury to normal tissue These side effects correlation to inflammatory process cause discomfort and decreases the therapeutic benefit by increasing the overall therapy time........ ]]> http://www.cancer-blog.org/blogs/permalinks/12-2008/dangerous-side-effect-for-lymphoma.html http://www.cancer-blog.org/blogs/permalinks/12-2008/dangerous-side-effect-for-lymphoma.html Fri, 19 Feb 2010 03:50:54 GMT Patients respond well to a new three-drug combination for indolent B cell lymphoma that also spares them prolonged, potentially lethal, suppression of blood production in the bone marrow, scientists at The University of Texas M. D. Anderson Cancer Center report today at the 50th annual meeting of the American Society of Hematology........ ]]> http://www.cancer-blog.org/blogs/permalinks/11-2008/new-platinum-phosphate-compounds-kill-ovarian-cancer.html http://www.cancer-blog.org/blogs/permalinks/11-2008/new-platinum-phosphate-compounds-kill-ovarian-cancer.html Fri, 19 Feb 2010 03:50:54 GMT A new class of compounds called phosphaplatins can effectively kill ovarian, testicular, head and neck cancer cells with potentially less toxicity than conventional drugs, as per a new study published this week in the journal Proceedings of the National Academy of Sciences. The compounds could be less harmful than current cancer therapys on the market such as cisplatin and carboplatin because they don't penetrate the cell nucleus and attach to DNA, said lead author Rathindra Bose. Conventional drugs can interfere with the functions of the cell's enzymes, which lead to side effects such as hearing and hair loss and kidney dysfunction........ ]]> http://www.cancer-blog.org/blogs/permalinks/7-2008/death-division-or-cancer.html http://www.cancer-blog.org/blogs/permalinks/7-2008/death-division-or-cancer.html Fri, 19 Feb 2010 03:50:54 GMT Each day, a staggering number of cells perform a feat that still amazes scientists with its complexity: they divide to produce perfect replicas of each other. The process is called mitosis, and an inability to control it is one of the hallmarks of cancer. Little is known about the biochemical processes that control mitosis, but now scientists from Fox Chase Cancer Center and Technion-Israel Institute of Technology in Haifa, Israel, have discovered a novel activity, called the mitotic checkpoint factor 2 (MCF2). This appears to be integral in preventing cells that are unable to equally separate their chromosomes from dividing. The identities of the proteins involved in MCF2 remain to be determined, however, their findings offer insight into a fundamental question of biology, which may also help to increase the efficiency of cancer drugs that disrupt DNA replication, like gemcitabine, or drugs that prevent mitosis, like paclitaxel........ ]]> http://www.cancer-blog.org/blogs/permalinks/5-2008/predicting-prostate-cancer-treatment-failure.html http://www.cancer-blog.org/blogs/permalinks/5-2008/predicting-prostate-cancer-treatment-failure.html Fri, 19 Feb 2010 03:50:54 GMT Dynamic contrast-enhanced MRI (DCE-MRI) plus diffusion weighted imaging (DWI) can accurately diagnose residual or recurrent prostate cancer in patients treated with high-intensity focused ultrasonic ablation, a new study shows. The study included 27 patients who had increased levels of prostate specific antigen after being treated with high-intensity focused ultrasonic (HIFU) ablation; 18 of these patients had local tumor progression seen at biopsy. DCE-MRI and DWI had about a 72% accuracy rate in determining which patients needed additional therapy because they had residual or recurrent cancer, said Chan Kyo Kim, MD, lead author of the study. The study observed that DWI had fewer false positives than DCE-MRI, but DCE-MRI had fewer false negatives........ ]]>