Carriers of a BRCA2 variation specific to Iceland are more likely to develop aggressive and lethal prostate cancer than noncarriers, as per a research studypublished online June 12 in the Journal of the National Cancer Institute
Mutations in the BRCA2 gene are linked to increased prostate cancer risk, but it has been unclear whether they are correlation to progression of the disease.

Laufey Tryggvadttir of the Icelandic Cancer Registry and his colleagues compared survival and disease progression in patients with prostate cancer with the Icelandic BRCA2 999del5 founder mutation and those without the mutation. Using a pool of male relatives of women with breast cancer, scientists identified patients with prostate cancer diagnosed in Iceland between 1955 and 2004. The mutation was present in 30 patients (5.7%).

The mutations carriers were younger at the time of diagnosis and had more advanced staged cancer, higher-grade tumors, and shorter median survival time (2.1 years vs. 12.4 years) compared with noncarriers.

The authors conclude that it is of great importance to study whether these results can be confirmed for carriers of mutations at other locations within the BRCA2 gene. Finally, the results indicate that in the search for new methods to predict prostate cancer progression, it may be fruitful to look for gene or protein expression patterns in prostate cancers resembling the patterns seen in BRCA2 mutation carriers.

In an accompanying editorial, Sholom Wacholder, Ph.D., of the National Cancer Institute in Bethesda, Md., and his colleagues discuss the limitations of this study and other similar studiesthe small number of mutation carriers, changes in screening practices, and the assumption that the date of diagnosis corresponds with the time of disease onset.

This work may clarify when and how BRCA2 mutations alter carcinogenesis. More generally, it offers an avenue for improving the accuracy of information available to patients when they are diagnosed with cancer. Nonetheless, the immediate clinical utility of these findings is limited, despite uncommonly rigorous design and analysis, the authors write.


Posted by: Jesmi24    Source

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