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KRAS rearrangements in metastatic prostate cancer

KRAS rearrangements in metastatic prostate cancer
Researchers have uncovered a genetic characteristic of metastatic prostate cancer that defines a rare sub-type of this disease. These findings appear in Cancer Discovery, the newest journal of the American Association for Cancer Research, which will debut at the AACR 102nd Annual Meeting 2011, held April 2-6. Arul M. Chinnaiyan, M.D., Ph.D., an investigator of the Howard Hughes Medical Institute and director of the Michigan Center for........Go to the Cancer-blog (Added on 4/3/2011 9:29:18 AM)


Potential cancer therapy

Potential cancer therapy
Alpha viruses, such as Sindbis virus, carry their genetic information on a single strand of RNA. On infection they use a protein, replicase, to produce double stranded RNA (dsRNA) which is used as genetic material to make more viruses. However the body recognizes dsRNA as foreign, and infected cells initiate an immune response. New research published in BioMed Central's open access journal BMC Cancer demonstrates that an artificial plasmid........Go to the Cancer-blog (Added on 3/28/2011 7:19:00 AM)


Cancer cells as ancient 'toolkit'

Cancer cells as ancient 'toolkit'
Despite decades of research and billions of dollars, cancer remains a major killer, with an uncanny ability to evade both the body's defenses and medical intervention. Now an Arizona State University scientist believes he has an explanation. "Cancer is not a random bunch of selfish rogue cells behaving badly, but a highly-efficient pre-programmed response to stress, honed by a long period of evolution," claims professor Paul Davies, director........Go to the Cancer-blog (Added on 2/7/2011 4:11:24 PM)


A loose grip provides better chemotherapy

A loose grip provides better chemotherapy
cientists at Case Western Reserve University have developed a little bomb that promises a big bang for cancer patients. Preliminary tests show an anti-cancer drug loosely attached to gold nanoparticles starts accumulating deep inside tumors within minutes of injection and can be activated for an effective therapy within two hours. The same drug injected alone takes two days to gather and attacks the tumor from the surface � a far less........Go to the Cancer-blog (Added on 2/5/2011 7:12:39 AM)


Prognosis with circulating tumor cells

Prognosis with circulating tumor cells
etastatic breast cancer patients whose blood contains circulating tumor cells (CTCs) before or after treatment with high-dose chemotherapy and blood stem cell transplant have shorter survival periods, according to a new study by researchers at The University of Texas MD Anderson Cancer Center in Houston. The findings were presented today in a poster session at the 33rd Annual CTRC-AACR San Antonio Breast Cancer Symposium. In addition,........Go to the Cancer-blog (Added on 12/13/2010 7:46:45 AM)


Types of Reconstruction for Women with Mastectomy

Types of Reconstruction for Women with Mastectomy
acing mastectomy (the removal of one or both breasts frequently due to cancer-as opposed to lumpectomy, which just removes a small portion of the breast) can be an emotional, challenging time for women who have been diagnosed with breast cancer. The act of thinking beyond the present and looking forward to moving on with one's life in the future has given a number of women the strength to make it through each day. If your doctor has advised........Go to the Cancer-blog (Added on 12/10/2010 7:38:36 AM)


A small molecule against cancer

A small molecule against cancer
A pioneering clinical trial is testing the effectiveness in leukemia of a small molecule that shuts down MDM2, a protein that can disable the well-known tumor suppressor p53. Michael Andreeff, M.D., Ph.D., professor of Medicine and chief of Molecular Hematology and Therapy in the Department of Leukemia at The University of Texas MD Anderson Cancer Center, presented preliminary results of this ongoing Phase I study at the 52nd Annual Meeting........Go to the Cancer-blog (Added on 12/8/2010 7:14:06 AM)


Genetic medicine and AMD treatment

Genetic medicine and AMD treatment
Genetic medicine is the focus of two presentations at today's Scientific Program of the 2010 American Academy of Ophthalmology (AAO) Middle East-Africa Council of Ophthalmology (MEACO) Joint Meeting. The AAO-MEACO meeting is in session October 16 through 19 at McCormick Place, Chicago. It is the largest, most comprehensive ophthalmic education conference in the world. Seeking Genetics-Specific Treatments for Age-Related Macular Degeneration........Go to the Health-blog (Added on 10/18/2010 7:30:51 AM)


New frontier in fighting cancer

New frontier in fighting cancer
A "game-changing" technique using near infrared light enables researchers to look deeper into the guts of cells, potentially opening up a new frontier in the fights against cancer and a number of other diseases. University of Central Florida chemists, led by Professor Kevin Belfield, used near infrared light and fluorescent dye to take pictures of cells and tumors deep within tissue. The probes specifically target lysosomes, which act as........Go to the Cancer-blog (Added on 9/1/2010 6:59:04 AM)


Reducing pain and depression of cancer

Reducing pain and depression of cancer
Pain and depression linked to cancer symptoms often unrecognized and undertreated can be significantly reduced through centralized telephone-based care management coupled with automated symptom monitoring, as per scientists from the Regenstrief Institute and Indiana University School of Medicine. The Indiana Cancer Pain and Depression (INCPAD) study combined automated calls with follow-up calls from the nurse care manager to reduce pain........Go to the Cancer-blog (Added on 7/14/2010 7:50:45 AM)


DNA discovery opens new door

DNA discovery opens new door
By solving the three-dimensional structure of a protein involved in repairing DNA errors, a group of McMaster University scientists have revealed new avenues to develop evaluation tools and alternative therapys for people living with hereditary colorectal cancers. The finding, reported in the journal Molecular Cell, is an important step forward in the field of molecular and structural biology. The McMaster scientists uncovered how a specific........Go to the Cancer-blog (Added on 7/9/2010 7:28:02 AM)


Off-the-shelf digital camera for cancer detection

Off-the-shelf digital camera for cancer detection
Using an off-the-shelf digital camera, Rice University biomedical engineers and scientists from the University of Texas M.D. Anderson Cancer Center have created an inexpensive device that is powerful enough to let doctors easily distinguish malignant cells from healthy cells simply by viewing the LCD monitor on the back of the camera. The results of the first tests of the camera were published online this week in the open-access journal PLoS........Go to the Cancer-blog (Added on 6/24/2010 10:20:19 PM)


Racial disparities diminish in specialized cancer centers

Racial disparities diminish in specialized cancer centers
A newly released study has observed that when African American and white cancer patients are treated at similar, specialized cancer care institutions, mortality rates are roughly equal. Published early online in Cancer, a peer-evaluated journal of the American Cancer Society, the findings suggest that where patients receive care may partly explain observed racial disparities in cancer mortality. In the newly released study, scientists led by........Go to the Cancer-blog (Added on 3/22/2010 7:39:44 PM)


Community Hospitals as Safe Surgical Option

Community Hospitals as Safe Surgical Option
Low-risk patients who require certain cancer surgeries can have the procedures performed with low operative mortality rates at community hospitals, as per a newly released study. The research showed that for 13 different kinds of cancer surgeries such as gastric and colon, younger patients with few pre-existing illnesses survived operations at community hospitals at a similar rate as at cancer centers. But patients who are considered high........Go to the Cancer-blog (Added on 2/3/2010 7:58:13 AM)


Quality radiation therapy

Quality radiation therapy
The American Association of Physicists in Medicine (AAPM) has issued a statement today in the wake of several recent articles in the New York Times yesterday and earlier in the week that discuss many rare but tragic events in the last decade involving people undergoing radiation treatment. While it does not specifically comment on the details of these events, the statement acknowledges their gravity. It reads in part: "The AAPM and its........Go to the Cancer-blog (Added on 2/1/2010 8:09:56 AM)


Targeting stem cells to fight ovarian cancer

Targeting stem cells to fight ovarian cancer
Eliminating cancer stem cells (CSCs) within a tumor could hold the key to successful therapys for ovary cancer, which has been notoriously difficult to detect and treat, as per new findings published this week in the journal Oncogene by Yale School of Medicine researchers. "We observed that stopping the expression of two genesLin28 and Oct4reduces ovary cancer cell growth and survival," said Yingqun Huang, M.D., assistant professor in the........Go to the Cancer-blog (Added on 1/28/2010 7:54:44 AM)


Robotic surgery for kidney cancer

Robotic surgery for kidney cancer
Fox Chase Cancer Center scientists find that outcomes of robotic assisted kidney cancer surgery, when performed by experienced surgeons at high volume centers, prove more beneficial to patients when in comparison to open surgery. The study, authored by Fox Chase robotic surgeon Rosalia Viterbo, MD, was presented today at the American Urological Association's Annual Meeting, . The standard therapy for kidney cancer is to surgically remove........Go to the Cancer-blog (Added on 4/27/2009 5:17:51 AM)


How radiation therapy causes chronic inflammation of bowels

How radiation therapy causes chronic inflammation of bowels
The use of radiation treatment to treat cancer inevitably involves exposure of normal tissues. Eventhough the benefits of this therapy have been well established, many patients experience distressing complications as a result injury to normal tissue These side effects correlation to inflammatory process cause discomfort and decreases the therapeutic benefit by increasing the overall therapy time. A research article would be published on........Go to the Cancer-blog (Added on 12/24/2008 5:11:48 AM)


New platinum-phosphate compounds kill ovarian cancer

New platinum-phosphate compounds kill ovarian cancer
A new class of compounds called phosphaplatins can effectively kill ovarian, testicular, head and neck cancer cells with potentially less toxicity than conventional drugs, as per a new study published this week in the journal Proceedings of the National Academy of Sciences. The compounds could be less harmful than current cancer therapys on the market such as cisplatin and carboplatin because they don't penetrate the cell nucleus and attach........Go to the Cancer-blog (Added on 11/19/2008 8:09:26 PM)


Death, Division or Cancer?

Death, Division or Cancer?
Each day, a staggering number of cells perform a feat that still amazes scientists with its complexity: they divide to produce perfect replicas of each other. The process is called mitosis, and an inability to control it is one of the hallmarks of cancer. Little is known about the biochemical processes that control mitosis, but now scientists from Fox Chase Cancer Center and Technion-Israel Institute of Technology in Haifa, Israel, have........Go to the Cancer-blog (Added on 7/1/2008 10:01:36 PM)

Researchers control growth rate of blood vessels

Researchers control growth rate of blood vessels
Scientists have discovered a way to control the growth rate of replacement tissue and the formation of new blood vessels, which solves one of the vexing problems of growing replacement tissue to treat injuries and trauma in humans. The procedure could be used in bone grafts, tissue replacement, dental procedures or for diabetics or elderly patients who experience wound healing problems, said William Giannobile, professor at the University of........Go to the Cancer-blog (Added on 3/9/2008 6:09:04 PM)

 

Disparities in progress against colorectal cancer

Disparities in progress against colorectal cancer
Progress in reducing colorectal cancer (CRC) mortality rates varies significantly across states, with rates in the Northeast showing the most progress and those in the South showing the least progress, as per a newly released study. As a result, the highest burden of CRC mortality shifted from the Northeast in the early part of 1990s to the southern states along the Appalachian corridor in the mid 2000s. The decrease in CRC mortality rates by........Go to the Cancer-blog (Added on 7/7/2011 8:58:59 AM)


Molecular disease model for melanoma

Molecular disease model for melanoma
Cancer Commons, an initiative of CollabRx, a provider of information technology to personalize cancer therapys and accelerate research, announces the publication of a molecular disease model of melanoma (MDMM) which classifies the disease into molecular subtypes, rather than traditional histological or cellular subtypes, and describes therapy guidelines for each subtype, including specific assays, drugs, and clinical trials. The paper, titled........Go to the Cancer-blog (Added on 3/31/2011 7:09:16 AM)


What You Should Know About Prostate Cancer Radiation Treatment

What You Should Know About Prostate Cancer Radiation Treatment
Prostate cancer is something that makes anyone nervous. Instead of going into this battle alone, there are many resources you can use to help you understand what you are up against. If prostate cancer radiation treatment is something that you will be undergoing, you might have many questions. You want to make sure that your doctor is providing you with any information you request about radiation therapy. If you have never underwent........Go to the Cancer-blog (Added on 3/5/2011 4:57:51 PM)


Y-90 radioembolization for liver cancer

Y-90 radioembolization for liver cancer
he latest weapon against inoperable liver cancer is so tiny that it takes millions of them per therapy, but as per interventional radiologists at the Indiana University School of Medicine, those microscopic spheres really pack a therapeutic punch. The glass spheres contain a radioactive element, yttrium-90, more usually known as Y-90, which emits radiation for a very limited distance so that healthy tissue around the tumor remains........Go to the Cancer-blog (Added on 12/15/2010 7:06:17 AM)


Trio of drugs may combat 'triple negative' breast cancer

Trio of drugs may combat 'triple negative' breast cancer
gene target for drug resistance, a triple-drug cocktail for triple negative breast cancer, and patients' risk for carpal tunnel syndrome are among study highlights scheduled to be presented by Johns Hopkins Kimmel Cancer Center researchers during the 33rd Annual CTRC-AACR San Antonio Breast Cancer Symposium, held Dec. 8-12. The information is embargoed for the time of presentation at the symposium. Working with cell cultures and mouse........Go to the Cancer-blog (Added on 12/13/2010 7:43:47 AM)


Pomegranate juice components inhibit cancer

Pomegranate juice components inhibit cancer
Scientists at the University of California, Riverside (UCR), have identified components in pomegranate juice that seem to inhibit the movement of cancer cells and weaken their attraction to a chemical signal that has been shown to promote the metastasis of prostate cancer to the bone, as per a presentation today at the American Society for Cell Biology's 50th Annual Meeting in Philadelphia. The scientists in the UCR laboratory of Manuela........Go to the Cancer-blog (Added on 12/13/2010 7:11:01 AM)


School-based program to cope with asthma

School-based program to cope with asthma
A school-based intervention program designed for adolescents with asthma significantly improves asthma management and quality of life for the students who participate, and reduces asthma morbidity, as per scientists in New York City, who studied the effect of the program aimed at urban youth and their medical providers. The Asthma Self-Management for Adolescents (ASMA) program is an eight-week intervention geared toward helping adolescents........Go to the Health-blog (Added on 12/8/2010 7:30:15 AM)


Gene prevents stem cells from turning cancerous

Gene prevents stem cells from turning cancerous
Stem cells, the prodigious precursors of all the tissues in our body, can make almost anything, given the right circumstances. Including, unfortunately, cancer. Now research from Rockefeller University shows that having too a number of stem cells, or stem cells that live for too long, can increase the odds of developing cancer. By identifying a mechanism that regulates programmed cell death in precursor cells for blood, or hematopoietic stem........Go to the Cancer-blog (Added on 10/15/2010 6:43:45 AM)


Nose drops to treat brain cancer

Nose drops to treat brain cancer
Scientists are reporting the development and successful initial testing of a new form of methotrexate the mainstay anticancer drug designed to be given as nose drops rather than injected. It shows promise as a more effective treatment for brain cancer, they say. The report appears in ACS' Molecular Pharmaceutics, a bi-monthly journal. Tomotaka Shingaki and colleagues note that brain cancer is difficult to treat, partly because current........Go to the Cancer-blog (Added on 9/23/2010 7:25:32 AM)


Inhibiting prostate cancer

Inhibiting prostate cancer
A kinase is a type of enzyme the body uses to regulate the functions of the proteins mandatory for cell growth and maintenance, and scientists have discovered that one in particular plays a key role in developing prostate cancer. "It's known as Mnk, and eventhough it appears not to be essential for normal cell maintenance, it's important for cancer growth" said Dr. Luc Furic, a postdoctoral researcher working with Dr. Nahum Sonenberg at McGill........Go to the Cancer-blog (Added on 8/10/2010 7:14:57 AM)


Multicolor quantum dots in cancer diagnosis

Multicolor quantum dots in cancer diagnosis
The tunable fluorescent nanoparticles known as quantum dots make ideal tools for distinguishing and identifying rare cancer cells in tissue biopsies, Emory and Georgia Tech researchers have demonstrated. An article to be featured on the cover of the July 15 issue of Analytical Chemistry describes how multicolor quantum dots associated with antibodies can distinguish the Reed-Sternberg cells that are characteristic of Hodgkin's lymphoma. ........Go to the Cancer-blog (Added on 7/7/2010 7:23:53 AM)


Automated telephone reminders

Automated telephone reminders
Simple, automated telephone reminders can increase colon cancer screening rates by 30 percent, as per a Kaiser Permanente Center for Health Research study funded by the National Cancer Institute that appears in the July print edition of Medical Care The study which is the first to examine whether automated calls can increase screening for colon cancer involved nearly 6,000 Kaiser Permanente members in Oregon and Washington who were overdue........Go to the Health-blog (Added on 6/24/2010 11:20:25 PM)


Natural Compound that Inhibits Cancer Cell Migration

Natural Compound that Inhibits Cancer Cell Migration
Investigators at Sanford-Burnham Medical Research Institute (Sanford-Burnham, formerly Burnham Institute for Medical Research) led by Kristiina Vuori, M.D., Ph.D., have discovered that the natural compound sceptrin, which is found in marine sponges, reduces cancer cell motility (movement) and has very low toxicity. Metastasis is one of the deadliest aspects of cancer, so restricting aberrant cell movement is an important step towards advancing........Go to the Cancer-blog (Added on 2/18/2010 9:50:54 PM)


How to kill pediatric brain tumors

How to kill pediatric brain tumors
Scientists at Washington University School of Medicine in St. Louis have shown once again that "ready, fire, aim," nonsensical though it may sound, can be an essential approach to research. The researchers robotically "fired" 2,000 compounds into culture plates containing tumor cells to see if the compounds had any effect. When the robotic screener found one substance had scored a hit by inhibiting growth of the tumor cells in its plate,........Go to the Cancer-blog (Added on 2/10/2010 8:04:49 AM)


Assessing risks associated with low-dose radiation

Assessing risks associated with low-dose radiation
There remains a lack of consensus amongst the medical and scientific communities about any cancer risk from low level radiation, especially low-dose radiation delivered from computed tomography (CT) scans. However, the study of epigenetics may play a role in determining whether or not future trends of diseases can in fact be associated with utilization of CT, as per an article in the recent issue of the Journal of the American College of........Go to the Cancer-blog (Added on 2/1/2010 7:39:41 AM)


Reversing Cancer Cell Metabolism And Tumor Growth

Reversing Cancer Cell Metabolism And Tumor Growth
A team of researchers led by Professor Adrian Krainer, Ph.D., of Cold Spring Harbor Laboratory has discovered molecular factors in cancer cells that boost the production of an enzyme that helps alter the cells' glucose metabolism. The altered metabolic state, called the Warburg effect, promotes extremely rapid cell proliferation and tumor growth. Discovered eighty years ago by Nobel Prize-winning scientist Otto Warburg, this altered........Go to the Cancer-blog (Added on 1/25/2010 8:11:42 AM)


Improved detection of bladder tumors

Improved detection of bladder tumors
Making tumors inside the bladder fluoresce red under blue light allows physicians to more easily find and remove them, substantially reducing the rate at which these cancers come back, says a Mayo Clinic doctor who is presenting results of a large, multicenter international clinical trial. VIDEO ALERT: Additional audio and video resources, including excerpts from an interview with Dr. Lance Mynderse describing the research, are available on........Go to the Cancer-blog (Added on 4/27/2009 5:22:29 AM)


SIRT1 takes down tumors

SIRT1 takes down tumors
Yuan et al. have identified another anti-cancer effect of the "longevity" protein SIRT1. By speeding the destruction of the tumor promoter c-Myc, SIRT1 curbs cell division. The study will be published online April 13 (www.jcb.org) and will appear in the April 20 print issue of the Journal of Cell Biology The yeast and nematode equivalents of SIRT1 are fountains of youth that stretch lifespan. Whether SIRT1 slows aging in mammals isn't........Go to the Cancer-blog (Added on 4/13/2009 1:32:48 PM)


New therapy prevents dangerous side effect for lymphoma patients

New therapy prevents dangerous side effect for lymphoma patients
Patients respond well to a new three-drug combination for indolent B cell lymphoma that also spares them prolonged, potentially lethal, suppression of blood production in the bone marrow, scientists at The University of Texas M. D. Anderson Cancer Center report today at the 50th annual meeting of the American Society of Hematology. Pentostatin, cyclophosphamide and rituximab together are providing the same remission rate as other........Go to the Cancer-blog (Added on 12/9/2008 10:29:32 PM)


Predicting prostate cancer treatment failure

Predicting prostate cancer treatment failure
Dynamic contrast-enhanced MRI (DCE-MRI) plus diffusion weighted imaging (DWI) can accurately diagnose residual or recurrent prostate cancer in patients treated with high-intensity focused ultrasonic ablation, a new study shows. The study included 27 patients who had increased levels of prostate specific antigen after being treated with high-intensity focused ultrasonic (HIFU) ablation; 18 of these patients had local tumor progression seen at........Go to the Cancer-blog (Added on 5/19/2008 6:40:36 PM)

Drug fends off kidney cancer progression

Drug fends off  kidney cancer progression
New data from an international, multicenter Phase III clinical trial has observed that the experimental targeted treatment everolimus (RAD001) significantly delays cancer progression in patients with metastatic kidney cancer whose disease had worsened on other therapys. The study was led by Robert Motzer, MD, an attending doctor at Memorial Sloan-Kettering Cancer Center (MSKCC), who will present the findings on May 31 at the annual meeting of........Go to the Cancer-blog (Added on 5/18/2008 9:45:02 PM)


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